Information and communication technology will face radical changes in the next decade. The changes are triggered by an application and software pull and a technology push: On the application side the Internetof- Things, Industry 4.0, and new Cyper-physical systems require low-energy distributed smart embedded devices which pre-process sensor data. Additionally, High-Performance Data Analysis (HPDA) software filters out relevant information from huge amounts of data, often in in combination with Deep Learning software running on High-Performance Computers (HPC). Both techniques come together in embedded HPC pushing Advanced Driver-Assistance Systems (ADAS) towards future Autonomous Vehicles. On the technology side several upcoming new technologies such as memristors and quantum computing will enable new application possibilities and challenge basic assumtions of computing potentially leading to a “reboot of computing” (US IEEE society) or a “re-invention of computing” (HiPEAC Vision 2017).